Hey, most likely this is something everyone overlooked, just as I have.
But a friend/customer (ahem :P) told me that one of our apps was looking weird. The reason was that he had turned on zoom in the accessibility settings on an iphone 6 and the layout broke rather badly - going off the screen (that was to be expected) and breaking proportions on top of that (this is bad).
That may be something that we can consider as unsupported; the problem was that after turning zoom off the app would crash every time it was started, until specifically killed and restarted.
I don’t know if accessibility zoom was taken into consideration, but it is a thing you should look into, at least.